INTEGRATIVE ANALYSIS OF GENOMIC SEQUENCING DATA REVEALS HIGHER PREVALENCE OF LRP1B MUTATIONS IN LUNG ADENOCARCINOMA PATIENTS WITH COPD

Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD

Abstract Both chronic Obstruction Pulmonary Disease (COPD) and lung cancer are leading causes of death globally.Although COPD and lung cancer coexist frequently, it is unknown whether lung cancer patients with COPD harbor distinct genomic characteristics compared to those without COPD.In this study, we retrospectively analyzed genomic sequencing da

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Mitochondrial Dynamics and Mitophagy in Cardiometabolic Disease

Mitochondria play a key role in cellular metabolism.Mitochondrial dynamics (fusion and fission) and mitophagy, are critical to mitochondrial function.Fusion allows organelles to share metabolites, proteins, and mitochondrial DNA, promoting complementarity between damaged mitochondria.Fission increases the number of mitochondria to ensure that they

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